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Amyotrophic Lateral Sclerosis (familial)

Prevalence: 1/50000

neurological

Official·OMIM:105400 Official·ORPHA803

Motor neuron disease due to SOD1, C9orf72, TARDBP, or FUS gene mutations.

Associated Genes

SOD1Superoxide Dismutase 1

Chromosome 21Autosomal Dominant

C9orf72C9orf72-SMCR8 Complex Subunit

Chromosome 9Autosomal Dominant

TARDBPTAR DNA Binding Protein

Chromosome 1Autosomal Dominant

FUSFUS RNA Binding Protein

Chromosome 16Autosomal Dominant