Genetic and Biochemical Markers of Interferon-Induced Depression.

Plain-language summary

This study examines the genetic and biochemical markers of depression that can develop with treatment in patients about to receive interferon therapy for hepatitis C. It enrolled patients aged 18 and older who tested positive for hepatitis C and were considered candidates for interferon therapy. The research was conducted as a study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

US Department of Veterans Affairs

Start date

4/1/2006

Estimated completion

9/1/2009

Countries

United States

Related genes

Locations

• Long Beach, United States
• Minneapolis, United States
• Portland, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. Serum positive for hepatitis C
2. Age 18 or older
3. Not pregnant and using adequate contraception
4. Hepatologist-determined patient is a candidate for interferon therapy
5. Written/signed informed consent specific for this protocol has been obtained prior to entry

Exclusion Criteria:

1. Diagnosis of active: depression, psychotic symptoms, or bipolar disorder (or history of bipolar disorder) during the previous 3 months
2. On antidepressant medications for any reason
3. Currently abusing any substances such as alcohol or intravenous drugs, or having abused in the past 6 months.