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This study investigates pulmonary hypertension (high pressure in the lung's blood vessels) in people with Sickle Cell Disease in Nigeria. It included Nigerians over age 5 with genetically confirmed sickle cell disease (SS, SC, or S-beta thalassemia) and healthy controls. It is an observational (non-phase) study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
* INCLUSION CRITERIA: All volunteer subjects 5 years of age and above and able to provide informed, written consent for participation in this study. Children will be included in this study provided that a legally authorized representative provides fully informed consent. Assent of children will also be required. Inclusion Criteria for Volunteers with Sickle Cell: * Nigerian male and females over 5 years of age * Diagnosis of sickle cell disease (electrophoretic documentation of SS, SC, or SBeta thalassemia or other genotype is required) Inclusion Criteria for Control Subjects: * Nigerian males and females over 5 years of age. * Electrophoretic documentation of hemoglobin A or AS genotype. EXCLUSION CRITERIA: Exclusion Criteria for Volunteers with Sickle Cell: * Hb A-only phenotype and sickle cell trait * Decisionally impaired subjects. * Persons not able to understand the investigational nature of the study or give informed consent. Exclusion Criteria for Control Subjects: * Diagnosis of sickle cell disease (electrophoretic documentation of SS, SC, SBeta thallassemia or other sickling genotype) * Decisionally impaired subjects. * Persons not able to understand the investigational nature of the study or give informed consent.