Water as Therapy in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Plain-language summary

This study examined the effect of drinking a prescribed amount of water in people with autosomal dominant polycystic kidney disease (ADPKD). It was open to people with confirmed ADPKD, normal kidney function and good general health. Run by the University of Kansas, it was a study without an assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

University of Kansas

Intervention

Water prescription

Start date

9/1/2008

Estimated completion

7/1/2009

Countries

United States

Related genes

Locations

• Kansas City, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* ADPKD verified by ultrasound, CT or MRI, family history or physical exam
* Normal creatinine clearance, calculated by Cockroft-Gault formulat
* Good general health
* Controlled blood pressure, \< 140/90
* Absence of urinary tract symptoms such as dysuria, hesitancy, diminished flow

Exclusion Criteria:

* Azotemia
* Uncontrolled hypertension
* Urinary tract symptoms, dysuria, hesitancy, diminished flow, gross hematuria
* Diabetes mellitus, cancer, hematologic disorder
* Unable to follow directions
* Solitary kidney
* History of CHF, liver dysfunction or hyponatremia
* Currently taking diuretics
* Nephrotic range proteinuria (3.5 g/day)