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This study investigates the genetic factors (genetic modifiers) that influence the development of severe liver disease in people with cystic fibrosis (CF). It is open, regardless of genotype and age, to CF patients with severe liver disease and portal hypertension. Run by the University of North Carolina, Chapel Hill, it is a study without an assigned phase; it is not currently recruiting but is still ongoing (active, not recruiting).
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Volunteers with CF, regardless of genotype and age, who have "severe" liver disease with portal hypertension (big spleen, i.e. "splenomegaly" and/or presence of enlarged vessels in the esophagus, i.e. esophageal varices) may be eligible to participate. This would include any person who has been evaluated for a liver transplant, or has already received a liver transplant. Exclusion Criteria: * History of Alcohol Abuse * History of Biliary Atresia * History of Clinically Significant Hepatitis Infection * History of Hepatic Vein Thrombosis * History of Liver Cancer * History of Portal Vein Thrombosis * History of Clinically Significant use of total parenteral nutrition (TPN) * History of Wilson's Disease