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This study evaluated the effects of diet modification and aerobic exercise on metabolism in postmenopausal women, also looking at race. It was open to non-smoking women aged 45-80, at least one year into menopause, with a BMI between 25 and 50. Run by the National Institute on Aging (NIA), it was a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Female * 45-80 yrs of age * Non-smoking for one year * BMI greater than 25 kg/m2 and less than 50 kg/m2 * Menopause over 1 year * Caucasian or African American ethnicity Exclusion Criteria: Both groups * Currently being treated for active cancer * Type 1 diabetes; insulin treatment; poorly controlled (fasting blood sugar over 160 mg/dl) * Allergic to lidocaine or heparin * Untreated dyslipidemia, receiving triglyceride-lowering meds * Other systemic disorders that are not medically treated and stable * Taking beta-blockers, oral steroids, warfarin or any other medications interfering with fat/muscle metabolism that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior) * Abnormal liver or renal function; chronic pulmonary disease (on supplemental oxygen); anemia * MMSE (Mini-Mental State Examination) below 24, dementia or unstable clinical depression by exam * Women of ethnicity other than Caucasian or African American * Symptomatic heart disease, coronary artery disease, congestive heart failure, or uncontrolled hypertension unless medically stabilized * Abnormal response to exercise test (chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising blood pressure above 240/120mm Hg, or other contraindications to exercise) Exercise plus weight loss group only * Medical history of CVD (cardiovascular disease) with symptoms limiting ability to exercise * Physical impairment limiting normal activity * Aerobically trained with VO2max greater than 2 SD (standard deviation) above age-adjusted mean