Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy

Plain-language summary

This study investigates the negative impact of statin (simvastatin) therapy on the maintenance of muscle mass in older men. It enrolled men aged 65-75 living in the Nottinghamshire area who either used simvastatin with muscle soreness or used no statin. This study had no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

University of Nottingham

Start date

6/1/2009

Estimated completion

12/1/2012

Countries

United Kingdom

Related genes

Locations

• Nottingham, United Kingdom

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Male
* 65-75yrs
* Simvastatin use with muscle soreness or no statin use
* Residing in Nottinghamshire area

Exclusion Criteria:

* Clotting disorders or previous Cerebral Vascular Accident /Transient Ischaemic Attack /Deep Vein Thrombosis
* Metabolic disease e.g. diabetes, thyroid dysfunction
* Inflammatory conditions e.g. Rheumatoid Arthritis, Crohn's Disease
* Tobacco smoker
* Lower limb circulation problems e.g. Claudication
* Epilepsy
* Renal pathology
* Respiratory problems including Asthma