Gene - Diet Interactions

Plain-language summary

This study compares the effects of diets rich in polyunsaturated fat (PUFA) versus saturated fat (SAFA) in people with different genetic types of the Pro12Ala polymorphism in the PPARG gene. It included people with a body mass index between 20 and 29, normal blood sugar, and specific PPARG genotypes. It was carried out as a study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Marjukka Kolehmainen

Intervention

PUFA-diet, SAFA-diet

Start date

8/1/2010

Estimated completion

12/1/2011

Countries

Finland

Related genes

Locations

• Kuopio, Finland

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* BMI \>20kg/m2 \<29kg/m2
* Pro12Pro and Ala12Ala genotypes of PPARG Pro12Ala polymorphism
* participation to METSIM-study (METabolic Syndrome in Men, currently \>10000 men included from the population living in Kuopio, principal investigator Markku Laakso)
* normoglycemia

Exclusion Criteria:

* type 2 diabetes
* other chronic diseases