An Adipocyte-Driven Mechanism For Weight Regain After Weight Loss: The Yo-Yo Effect

Plain-language summary

This study examined the role of fat cells (adipocytes) in regaining weight after weight loss (the yo-yo effect), using a Modifast meal-replacement diet. It enrolled non-smokers aged 20 to 65 with a body mass index of 28 to 35. It was conducted as a trial with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Maastricht University Medical Center

Intervention

Meal replacement diet using Modifast, Normal diet combined with Modifast diet

Start date

3/1/2012

Estimated completion

11/1/2014

Countries

Netherlands

Related genes

Locations

• Maastricht, Netherlands

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age (years): 20-65
* Body Mass Index (kg/m2): 28-35
* Non-smokers

Exclusion Criteria:

* Subjects using prescription medication, or suffering from diseases or conditions that might influence the outcome of the study: this concerns diseases/medication that influence body weight regulation (malabsorption, untreated hypo/hyperthyroidism, eating disorders, systemic use of steroids, etc.) and obesity-related cardiovascular risk factors (heart disease, systolic and diastolic blood pressures \> 160/100 mmHg, blood glucose \> 6.1 mmol L-1, blood cholesterol \> 7 mmol L-1, blood triglycerides \> 3 mmol L-1)
* marked alcohol consumption \> 21 alcoholic units week-1 (male), or \>14 alcoholic units week-1 (female)
* planned major changes in physical activity during the study to an extent that might interfere with the study outcome as judged by the investigator;
* blood donation within the past 2 months prior to the study
* weight change of \>3 kg within 2 months prior to the study
* psychiatric disease (based on medical history only)
* pregnant or lactating women, or women planning to become pregnant within the next 12 months
* surgically treated obesity
* participation in other clinical studies within the last 3 months
* drug abuse (based on clinical judgment)
* unable to give informed consent
* unable to engage in a low-calorie diet
* unable to lose more then 8% of body weight after weight-loss period
* following a special diet (vegetarian, Atkins or other).