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This study examines differences in gene expression during wound healing after dental implant surgery in people who smoke and people with diabetes. It enrolled generally healthy people aged 18-70 who were going to receive one or more dental implants. It was carried out as a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Adult males or females between the age of 18 and 70 years (inclusive) * Able and willing to follow study procedures and instructions * Have read, understood and signed an informed consent form * In good general health * Have one or more implant placements as their future treatment needs. The implant placement can be either as one-stage or two-stage, and can be either in an edentulous ridge or an extraction socket * Qualify for enrollment into one of the three study groups * Have probing depth ≤ 4 mm for all teeth at the same quadrant of implant placement. Sites with probing depth 5 mm will also be included if bleeding on probing in these sites are absent. Exclusion Criteria: * Have a chronic disease with oral manifestations * Exhibit gross oral pathology * Use of either antibiotics or NSAIDs within 1 month prior to screening examination * Chronic treatment (i.e. two weeks or more) with any medication known to affect periodontal status (e.g. phenytoin, calcium, antagonists, cyclosporin, Coumadin) within 1 month prior to screening examination * Systemic conditions, except smoking and diabetes, that are known to affect the periodontal status * With active infectious diseases such as hepatitis, HIV or tuberculosis * Known to be pregnant or breastfeeding