Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes

Plain-language summary

This study examines how insulin regulates the breakdown of fat (lipolysis) in tissues of people with type 2 diabetes, using a hyperinsulinemic euglycemic clamp method. It enrolled people with normal blood pressure whose weight had been stable over the previous 3 months. It was carried out as a study without an assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Maastricht University Medical Center

Intervention

Hyperinsulinemic euglycemic clamp

Start date

6/1/2007

Estimated completion

9/1/2011

Countries

Netherlands

Related genes

Locations

• Maastricht, Netherlands

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Caucasian
* Normal blood pressure (SBP 100-140 mmHg, DBP 60-90 mmHg)
* weight stable in last 3 months

Exclusion Criteria:

* Smokers
* people with intensive fitness training (e.g. athletes \> 3 times/week)
* History of cardiovascular diseases
* Bleeding disorders
* Use of medication interfering with the study endpoints/hypotheses (e.g. beta-blockers)
* Not to be able to understand the study information
* Subjects on a special diet or vegetarian
* Blood donation 2 months prior to the study and during the study
* Participating in an other study