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This study examines the effects of medium-chain triglycerides on chylomicron secretion and on the expression of genes that regulate intestinal fat metabolism in men with dyslipidemia (abnormal blood fats) linked to metabolic syndrome, with corn oil used for comparison. It enrolled men aged 18-60 with a large waist circumference and high blood fats. It was carried out as a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Men aged between 18-60 years * Waist circumference \> 102 cm * HDL-cholesterol \< 1.1 mmol/L * Triglycerides \> 1.7 mmol/L * Fasting blood glucose \> 6.1 mmol/L * Normal blood pressure (\<130/85) Exclusion Criteria: * Women * Men \< 18 or \> 60 years * Smokers (\> 1 cigarette/day) * Body weight variation \> 10% during the last 6 months prior to the study baseline * Subjects with a previous history of cardiovascular disease * Subjects with type 2 diabetes * Subjects with a monogenic dyslipidemia * Subjects on hypertension medications or medications known to affect lipoprotein metabolism or the integrity of gastrointestinal mucosa * Subjects with endocrine or gastrointestinal disorders * History of alcohol or drug abuse within the past 2 years * Subjects who are in a situation or have any condition that, in the opinion of the investigator, may interfere with optimal participation in the study.