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This study examined the effect of Prebiotics+Glutamine supplementation compared with placebo in people with HIV infection. It included HIV-positive people over 18 grouped by treatment and immune status, as well as healthy controls. The study was conducted in Phase 1/Phase 2 and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * After receiving information on the design and objectives of the study, the possible risks involved, and the fact that they can refuse to collaborate at any time, patients will give their informed consent to participate in the study and agree to provide material for the cellular and molecular studies. * Aged over 18 years. * Group 1: HIV+, Not receiving ART and no previous exposure to ART, at least 2 years since HIV diagnosis. * Group 2: HIV+, currently receiving ART for more than 2 years, HIV-1 RNA levels less than 40 copies/ml and more than 350 CD4+ T-cells/uL. * Group 3: HIV+, currently receiving ART for more than 2 years, HIV-1 RNA levels less than 40 copies/ml and less than 350 CD4+ T-cells/uL. * Group 4: HIV-, healthy controls. Exclusion Criteria: * Major cardiovascular risk factors. * Concomitant acute diseases. * Gastrointestinal disorders. * Pregnancy. * Antibiotic exposure in the previous month. * Regular use of foods or supplements containing prebiotics or probiotics within the 2 weeks prior to initiation of the study.