Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer

Plain-language summary

This study evaluates blocking voltage-gated sodium channels with lignocaine (a local anesthetic) during surgery in women with operable breast cancer. It included women with confirmed or suspected breast cancer scheduled for surgery. It was a Phase 3 study, ongoing but not currently recruiting.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Phase 3

Status

Active, not recruiting

Sponsor

Tata Memorial Hospital

Intervention

0.5% lignocaine 60mM

Start date

12/12/2011

Estimated completion

12/31/2026

Countries

India

Related genes

Locations

• Guwahati, India
• Ahmedabad, India
• Kannur, India
• Kolhāpur, India
• Mumbai, India
• Pune, India
• Sangli, India
• Shillong, India
• New Delhi, India
• Hyderabad, India
• Delhi, India

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. All women with operable breast cancer planned for upfront surgery
2. Histologically proven or clinically suspicious breast cancer

Exclusion Criteria:

1. Previous history of lumpectomy or incision biopsy
2. Distant metastases
3. Neoadjuvant Chemotherapy
4. History of allergy to drugs (lignocaine)
5. High risk factors precluding the use of lignocaine
6. Previous history of cancer