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This study examines postprandial lipemia, meaning blood fat levels after eating, in adults at very high cardiovascular risk. Adults aged 18 and older with fasting triglycerides below 220 mg/dl and very high cardiovascular risk features were able to take part. It was conducted as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Male or female patients ≥ 18 years of age, * Signed informed consent form * Fasting triglycerides (TGs) \< 220 mg/dl * Liver function tests within normal range * No more than mild renal impairment (clearance of creatinine \>60 ml/min) * features of very high risk * documented cardiovascular disease by invasive or non-invasive testing (such as coronary angiography, nuclear imaging, stress echocardiography, carotid plaque on ultrasound) * previous myocardial infarction * acute coronary syndrome * coronary revascularization (percutaneous coronary intervention, coronary artery bypass graft) and other arterial revascularization procedures * ischemic stroke * peripheral artery disease * patients with type 2 diabetes * patients with type 1 diabetes with target organ damage * calculated 10 year risk SCORE ≥10%\] or * high risk, markedly elevated single risk factors such as: * familial dyslipidemias and severe hypertension * calculated SCORE ≥5% and \<10% Exclusion Criteria: * history of liver, kidney, pancreas, or gall bladder disease, * history of acute coronary syndrome one month prior to entering the study * pregnancy * presence of any inflammatory disease * treatment with medications known to affect TGs metabolism or concentration