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This study compares low, moderate, and high carbohydrate diets to understand how they affect the body's use of metabolic fuels. Adults aged 18-65 with a body mass index of 25-40 (weight no more than 300 lbs) who were students or employees at the host university were able to take part. It was conducted as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: Inclusion Criteria (as detailed in Framingham State Food Study, NCT02068885) * Aged 18 to 65 years * BMI ≥ 25 kg/m2 * BMI \< 40 kg/m2 and weight ≤ 300 lbs (136 kg) * Medical clearance from a primary care provider * Student or employee at Framingham State University throughout enrollment in the study * Willing and able to eat and drink only the foods and beverages on the study menus * Willing to eat in the dining hall * Willing to abstain from consuming alcohol during participation Additional Inclusion Criteria: • Willing to undergo additional procedures in this ancillary study Exclusion Criteria: Exclusion Criteria (as detailed in Framingham State Food Study, NCT02068885) * Change in body weight exceeding ±10% during prior year * Recent adherence to a special diet * Recent adherence to a vigorous physical activity regimen (e.g., participation in a varsity sport) * Chronic use of any medication or dietary supplement that could affect study outcomes * Current smoking (1 cigarette in the last week) * Heavy baseline alcohol consumption or history of binge drinking * Physician diagnosis of a major medical/psychiatric illness or eating disorder * Abnormal blood glucose, TSH, CBC, BUN, Creatinine * ALT greater than 150% of the normal upper limit * Plans for a vacation during the study that would preclude adherence to prescribed diet * Additional exclusions for female participants: Irregular menstrual cycles; any change in birth control medication during the 3 months prior to enrollment; pregnancy or lactation during the 12 months prior to enrollment Additional Exclusion Criteria: * Allergy or prior reaction to Lidocaine * Medical condition or medication that would increase risk of bleeding, infection or skin reactions