Predisposition Genes in Monogenic Diabetes (DIAMONO)

Plain-language summary

This study investigated new genes that predispose people to single-gene (monogenic) diabetes using blood samples. It included families with no mutations in the known MODY genes (GCK, HNF1A, HNF4A) and with several cases of diabetes across multiple generations. It was conducted as a non-phase study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Assistance Publique - Hôpitaux de Paris

Intervention

blood sample

Start date

9/1/2012

Estimated completion

10/1/2015

Related genes

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* No mutations in known genes associated with MODY (GCK, HNF1A, HNF4A)
* ≥ 3 cases of diabetes in the family over several generations
* An age at diagnosis of diabetes \<40 years for 3 subjects diabetics in the family
* Absence of anti-GAD and anti-A2 of antibodies
* No argument for type 2 diabetes

Exclusion Criteria:

* Diabetic subjects
* Healthy subjects whose relationship is relevant for genetic analysis and necessary for the validation step (family cosegregation study)
* These subjects will be over the age of 18, affiliated to a social protection scheme or copyright holder and will signed an informed consent