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This study examined the relationship between FGF-21 levels and resting metabolic rate in children and adolescents with Hashimoto's thyroiditis. It included patients aged 5 to 18 with a first diagnosis of chronic autoimmune thyroiditis, along with healthy individuals of the same age as a control group. It was a non-phase study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: For patients * Subjects 5 to 18 years old. * First diagnosis of chronic autoimmune thyroiditis (high levels of serum antithyroid autoantibodies anti-TPO, anti-TgAb). For Controls: * Healthy individuals 5 to 18 years old. * BMI for age between 15th and 85th percentile (z-score between -1 and +1). Exclusion Criteria: For patients * Pre-existing medical treatment for thyroid disease * Taking other medications (eg growth hormone, corticosteroids) in the last 3 months. * Taking food supplements (eg omega-3 fatty acids, amino acids) in the last 3 months. * Concomitant endocrine, metabolic, degenerative, and/or chronic diseases other than obesity (eg diabetes, hyper/ hypercortisolemia, cardiovascular diseases, kidney diseases, myasthenia, neurological diseases, psychiatric disorders eg anorexia nervosa, cancer, anemia, celiac disease, chromosomal abnormalities eg syndrome Turner, Down, etc). * Participation in any daily organized physical activity (sport), more than 1 hour per day. * Presence of menstrual disorders in adolescent girls. * Having any kind of nutrition/dietary intervention (eg weight loss diet, hypocaloric, ketogenic, low-protein diet), in the last 6 months. For Controls: * Presence of any form of thyroid disease. * Presence of any endocrine, metabolic, degenerative, and/or chronic disease (eg diabetes, hyper/ hypercortisolemia, obesity, metabolic syndrome, cardiovascular diseases, kidney diseases, myasthenia, neurological diseases, psychiatric disorders eg anorexia nervosa, cancer, anemia, celiac disease, chromosomal abnormalities eg syndrome Turner, Down, etc). * Taking any medication (eg growth hormone, corticosteroids) in the last 3 months. * Taking food supplements (eg omega-3 fatty acids, amino acids) in the last 3 months. * Participation in any daily organized physical activity (sport), more than 1 hour per day. Presence of menstrual disorders in adolescent girls. * Having any kind of nutrition/dietary intervention (eg weight loss diet, hypocaloric, ketogenic, low-protein diet), in the last 6 months.