Whole Genome Single Nucleotide Polymorphisms in Elderly Patients With Postoperative Cognitive Dysfunction

Plain-language summary

This study used genotyping to examine whole-genome single nucleotide polymorphisms in elderly patients who developed postoperative cognitive dysfunction. It included patients undergoing major non-cardiac surgery under general anesthesia. It was a non-phase study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

University Hospital, Basel, Switzerland

Intervention

Whole genome small nucleotide polymorphism genotyping

Start date

8/1/2007

Estimated completion

10/1/2011

Countries

Switzerland

Related genes

Locations

• Basel, Switzerland

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status I-IV
* Major noncardiac surgery under general anesthesia
* Native German or French speakers

Exclusion Criteria:

* Cardiac surgery
* Neurosurgery
* Surgery within 12 months prior to inclusion
* History of intracranial or cerebrovascular pathology
* Preoperative Mini-Mental State Examination (MMSE) score \<24
* Psychiatric disease and long-term psychopharmacological treatment