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This study examined treatment outcomes with the antidepressant drugs Escitalopram and Duloxetine in patients with major depressive disorder. It included people aged 18 to 65 with moderate to severe depression who had not received antidepressant treatment in the past 2 months. It was conducted in Phase 1 and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Moderate to severe depression * Age 18-65 years * No previous antidepressant treatment the last 2 months * Informed and signed consent Exclusion Criteria: * More than one previous attempt with antidepressant drugs * Duration of current depression more than 2 years * Current or previous psychiatric severe co-morbidity * Acute suicidal ideation * Psychotic * Previous non-response to Selective Serotonin Reuptake Inhibitor (SSRI) * Contraindication for SSRI treatment * More suitable with treatment of alternative anti-depressive drug. * Severe somatic co-morbidity * Somatic medicine that can influence the trial * Contraindications for MR-scanning * Previous exposure to radioactivity \> 10 milli sievert (mSv) within the last year * Alcohol or drug abuse * Previous severe head trauma * Pregnancy * Breast-feeding * Insufficient Danish skills