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This study examined phenotypic changes in monocytes (a type of immune cell) in patients with heart failure. It included patients aged 18 and older hospitalized for heart failure, as well as healthy volunteers aged 65 and older. It was a non-phase study that has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: Heart Failure Patients: * 18 years of age or older * Patients must be diagnosed with heart failure * Patients must be hospitalized at the University of Michigan Hospital for treatment of heart failure symptoms. Exclusion Criteria: Heart Failure Patients: * Heart attack or other active problem with coronary artery disease * Severe kidney failure or need for dialysis * An active infection or inflammatory condition * A need for treatment that affects the immune system (e.g. systemic steroids, immunomodulatory therapies) * A planned surgery during this hospital admission, including heart transplant or other heart surgery Inclusion Criteria: Healthy Control Patients: \- Must be greater than or equal to 65 years of age Exclusion Criteria: Healthy Control Patients: * Diabetes * High blood pressure * Active cancer * Heart disease * Lung disease * Liver disease * Kidney disease * Active smoker