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This study compares the effects of a diet high in saturated fat with a diet low in saturated fat on blood cholesterol levels. It was designed for healthy people with a body mass index of 19-32 whose fasting cholesterol and triglyceride values were below defined limits. The study was conducted as a trial without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * BMI of 19-32 kg/m2 * Fasting serum total cholesterol \< 7.5 mmol/l and triacylglycerol \< 2.3 mmol/l Exclusion Criteria: * Smokers * Medical history of myocardial ischemia or stroke in the past 12 months; * Diabetes (defined as fasting glucose \> 7.0 mmol/l) or other endocrine disorders; kidney, liver, pancreas or gastrointestinal disorders * Hypertension (blood pressure \> 140/90 mmHg), * Cancer * Medication for hyperlipidaemia (e.g. statins), hypertension, inflammation or prescribed antibiotics within the last three months * Drinking in excess of 14 units of alcohol per week, * Anaemia (\<130 g/L haemoglobin), or planning on a weight-reducing regime * Taking any dietary supplements known to influence lipids/gut microbiota (eg. plant stanols, fish oil, phytochemicals, natural laxatives, probiotics and prebiotics) * Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study.