KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT)

Plain-language summary

This study examines how polymorphisms in the KCNH2 gene affect the heart-related QTc interval in Malay patients receiving methadone maintenance therapy. Eligible participants are opioid-dependent patients of Malay ancestry aged 18 or older who have been on this therapy for at least six months. It was conducted as an observational study without a formal phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Universiti Sains Malaysia

Start date

2/1/2011

Estimated completion

12/31/2012

Countries

Malaysia

Related genes

Locations

• Kubang Kerian, Malaysia

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Opioid-dependent subjects aged 18 years and above
* Opioid-dependent subjects who were on Methadone Maintenance Therapy (MMT) for 6 months or longer and had stable plasma methadone concentration
* Malay ancestry up to 3 generations
* A history of good compliance with Directly-Observed Therapy (DOT)

Exclusion Criteria:

* Opioid-dependent subjects who were aggressive and had active psychiatric illnesses
* Opioid-dependent subjects with chronic medical and surgical illnesses
* Opioid-dependent subjects with cardiac structural defects
* Inability to communicate in Malay or English