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This study examines the characteristics of bone marrow fat cells in the ageing of bones and joints, in osteoarthritis and in osteoporosis. Post-menopausal women with symptomatic knee osteoarthritis requiring a prosthesis may take part, and tissue samples are evaluated. It is a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Post-menopausal woman * with a symptomatic knee osteoarthritis requiring prosthesis * able to handle general anaesthesia * having given her consent * able to understand the constraints associated with the study * with health insurance * able to understand the French language Exclusion Criteria: * with refusal to participate to the study * more than 85-year-old * with bone pathologies other than osteoarthritis or osteoporosis * with active infection * with evolving cancer * with haematopoietic pathologies such as haemoglobin pathologies * with thyroid pathologies * with type 1 diabetes * with anti-osteoporotic treatments (bisphosphonates, strontium ranelate, teriparatide, denosumab) except calcium and vitamin D supplementation or hormone replacement. * with replacement of prosthesis * with previous surgery at the surgery site --with a current participation to another study * with guardianship * with deprived liberty