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This study examined enhancing hippocampal plasticity in the brain using repetitive transcranial magnetic stimulation (TMS; TBS method). People aged 50 to 85 with mild cognitive impairment or with normal cognition were eligible. The study had no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Individuals with mild cognitive impairment (MCI Group) Inclusion Criteria: * Age 50-85 years * MCI clinical criteria: (a) typical comprehensive criteria (at least one cognitive test \<= -1.5 SD), or (b) Jak/Bondi criteria (2 tests within the same domain \<= -1SD or 3 tests total \<= -1SD) * Right handed * English speaking * Able to attend daily intervention (Monday-Friday) for 4 weeks * Not enrolled in another interventional study within 6 months prior to beginning this study Exclusion Criteria: * Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI) * Other neurological disorders (e.g. stroke, head injuries, or multiple sclerosis) * Current cancer treatment or other medical problems that might independently affect cognitive function Cognitively Normal Individuals: Inclusion Criteria: * Age 50-85 years * Right handed * English speaking * Able to attend daily intervention (Monday-Friday) for 4 weeks * Not enrolled in another interventional study within 6 months prior to beginning this study Exclusion Criteria: * Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI) * Other neurological disorders (e.g. stroke, head injuries, or multiple sclerosis) * Current cancer treatment or other medical problems that might independently affect cognitive function * No dementia or impaired cognitive functioning, assessed using the NACC battery.