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This study examines the relationship between de novo lipogenesis (the body's production of new fat) and insulin sensitivity in obese and normal-weight women, using fasting/refeeding and a ketogenic diet. It enrolled sedentary, premenopausal, normal-weight and obese women aged 25 to 40. It was a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * sedentary premenopausal women * lean (n=20-25, age 25-40 years, BMI 20-25 kg/m2) * obese (n=20-25, age 25-40 years, BMI 30-40 kg/m) Exclusion Criteria: * diagnosed cancer * diabetes (T1DM and T2DM) * liver and renal diseases * major cardiovascular event * bariatric surgery * allergy to lidocaine * positive serology for hepatitis (B and C) and HIV * smoking above 10 cigarettes/day, alcohol consumption above 66g/day * sleep apnea * poor venous status * weight-change more than 3kg in last 3 months * untreated hyper- or hypo-thyroidism * long term use of medication and/or steroids * shift workers and individuals with abnormal sleep/wake pattern