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This study examined changes in the brain-gut axis after weight-loss (bariatric) surgery and how these relate to weight loss. Women aged 18-55 approved to undergo laparoscopic gastric bypass or sleeve gastrectomy were eligible. It was a non-phase study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Women, age 18-55 years * Eligible and approved for undergoing laparoscopic gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) following the Guidelines for Clinical application of Laparoscopic Bariatric Surgery by of American Gastrointestinal and Endoscopic Surgeons (SAGES) * Right-handed Exclusion Criteria: * Previous major gastrointestinal surgery including weight loss surgery (partial or complete resection of stomach and/or small bowel, Whipple procedure, etc) * Use of medications known to affect hunger, satiety, or intestinal motility. * Unwillingness or inability to give informed consent * Any contraindication to undergo MRI * Current or past alcohol or drug abuse problem or smoking * Pregnancy, lactating or post partum less than 12 months * Body weight at enrollment greater than 350 lbs. * Current use of insulin and or insulin dependent diabetes * Renal insufficiency, retinopathy, or neuropathy. * Post menopausal (defined as no menses for 12 consecutive months)