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This study examined the molecular pathways involved in knee pain through various assessments and tests (sensory testing, radiography, ultrasound-guided joint fluid aspiration and others) in people with knee pain. People aged 45 and over with 3-6 months of knee pain were eligible. It was a non-phase study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * have the ability to give informed consent * be 45 years or over * have complaints of knee pain for 3-6 months with or without radiographically established OA (K/L scale score ≥ 1) * have complaints of knee pain for 3-6 months with or without satisfying the non-radiographic American College of Rheumatology criteria for knee OA * are willing to undertake knee synovial fluid aspiration * be able to speak, read, and write in English as all instructions and questionnaires are designed in the English language Exclusion Criteria: * Inability to give informed consent due to cognitive impairment or otherwise - (capacity levels are already established under General Practitioner care) * Inability to understand key aspects of the study due to cognitive impairment or otherwise * Giving history of additional co-morbidities such as cancer, neurological conditions, inflammatory joint diseases including rheumatoid arthritis, diabetic neuropathies, fractures or other conditions causing greater disability than their knee pain * Acute soft tissue injury to the knee within last 3 months before potential recruitment