Sweet Tooth: Nature or Nurture? Role of Long-term Dietary Sweetness Exposure on Sweetness Preferences

Plain-language summary

This study examined the role of long-term dietary sweetness exposure on people's sweetness preferences through a dietary intervention. People aged 18-65 in good general health, with a body mass index of 18.5-30 and normal taste ability, were eligible. It was a non-phase interventional study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Wageningen University

Intervention

Dietary intervention

Start date

10/20/2020

Estimated completion

6/5/2024

Countries

Netherlands

Related genes

Locations

• Wageningen, Netherlands

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Good general health;
* Age 18 - 65 years;
* Body mass index 18.5 - 30 kg/m2;
* Having normal taste ability (assessed with taste strips test);
* Having normal glucose levels in blood (assessed with a finger prick);
* Able to provide informed consent;
* Able to attend Wageningen University, as required for testing.

Exclusion Criteria:

* Diagnosed with diabetes currently or in the past;
* Has been notified to have insulin resistance currently or in the past;
* Diagnosed with endocrine diseases or other metabolic diseases that influence metabolism;
* Diagnosed with eating disorders;
* Diagnosed with taste or smell disorder;
* Pregnant or lactating during the study intervention;
* Gain or loss of more than 3 kg in the last three months prior to study entry;
* Suffering from lack of appetite (self-report);
* Use of medication that may influence study results; such as medication that may affect blood sugar;
* Having a food allergy or/and food intolerance for foods used in the preference testing (e.g. lactose intolerance, celiac disease, egg allergy);
* Consumes more than 14 glasses of alcohol per week;
* Use of soft or hard drugs (e.g. cannabis);
* Student or personnel of Nutrition and Health at Wageningen University;
* Participating in another study/studies or planning to participate in another study.

Specific criteria for withdrawal:

* Pregnancy;
* Weight change of 4 kg or more. In a case of systematic weight change - a subject has gained or lost 4 kg or more at the 3-month period, he/she will be excluded from the study (stop criterion).