Universal Familial Hypercholesterolemia Screening in Children

Plain-language summary

This study evaluated a universal screening program for familial hypercholesterolemia in children, using lipid level measurements and genetic analysis. It included children with elevated cholesterol found through the screening program, as well as family members of children with confirmed disease. This was a study without an assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

University of Ljubljana, Faculty of Medicine

Intervention

Genetic analysis, Lipid levels measurement

Start date

1/1/2019

Estimated completion

12/31/2021

Countries

Germany, Slovenia

Related genes

Locations

• Hanover, Germany
• Ljubljana, Slovenia

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Elevated total cholesterol (cohort 1) or LDL-cholesterol (cohort 2) at universal screening program in children.
* Completed FH genetic analysis (cohort 3).
* Parent or sibling of child with confirmed familial hypercholesterolemia (cohort 4).

Exclusion Criteria:

* Children with hypercholesterolemia not referred through the screening program.
* FH genetic analysis not completed.