Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH

Plain-language summary

This study assesses heart function using the pressure-volume (PV) loop method in patients with idiopathic pulmonary arterial hypertension or scleroderma-associated pulmonary hypertension. It enrolled patients aged 18 and older who had received these clinical diagnoses. The study was conducted as a non-phase study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Johns Hopkins University

Start date

4/15/2019

Estimated completion

12/31/2025

Countries

United States

Related genes

Locations

• Baltimore, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Patients 18 years or older with clinically diagnosed scleroderma or presumed/known idiopathic pulmonary hypertension.

Exclusion Criteria:

* Patients found to have secondary pulmonary hypertension (PH due to left heart failure) on clinical RHC.
* Hemodynamically unstable patients (systolic blood pressure \< 90mmHg, vasopressor requirement).
* Patients whom are unable to give consent for themselves.
* Patients with RV clot or septal aneurysm will be excluded.
* In order to undergo the clinical right heart catheterization procedures, pregnancy testing (urine or serum) is standard of care.
* Pregnancy