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This study compares blood flow restriction exercise with traditional resistance exercise to see how they affect muscles and blood vessels in people with spinal cord injury. Adults aged 18-75 with an incomplete spinal cord injury (AIS C or D) that occurred at least one year earlier could take part. It was a study without a phase designation and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * All participants must be between the ages of 18 and 75 years and have a medically stable incomplete spinal cord injury (AIS C or D) at least 1-year post injury * As the aim of this investigation is to focus on muscular and vascular adaptations to BFR exercise in the lower limbs, the level of injury must be between C3-L1 Exclusion Criteria: The following are the exclusion criteria: * Females that are pregnant * Individuals required to have ventilator assist devices * Individuals with significant active systemic disease, e.g. heart disease, renal failure/insufficiency and uncontrolled diabetes, uncontrolled hypertension and blood disorders that increase the risk for clot formation. * Individuals with chronic inflammatory disease states (i.e. multiple sclerosis or rheumatoid arthritis, Guillen-Barre syndrome, chronic inflammatory demyelinating disorder and acute amyotrophic lateral sclerosis) * Obese patients (\>30% body fat based on skinfold measurements) * History of repeated DVTs or a DVT within the last year. * Individuals currently taking vasodilators * Individuals with orthopaedic limitations that would prevent them from performing knee extension/flexion exercise (with the exception of decreased strength due to the SCI) * Individuals with uncontrolled spasticity or a history of frequent autonomic dysreflexia