Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure

Plain-language summary

This study compares the effects of combining cognitive and physical exercise training on thinking (cognition) and brain blood flow in people with chronic heart failure. Patients aged 50 and over with stable chronic heart failure for at least 2 months could take part. It is a study without a phase designation and is still recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Montreal Heart Institute

Intervention

Cognitive training, Exercise training, Usual care

Start date

9/1/2021

Estimated completion

12/1/2026

Countries

Canada

Related genes

Locations

• Montreal, Canada

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age ≥ 50 years old
* Stable chronic HF on maximally tolerated background treatment for at least 2 months (stable therapy with ACE-I, ARBs and MRA for at least 2 months), regardless of LVEF
* with no limitation of physical activity in ordinary physical activity (i.e. NYHA class I), moderate symptoms (i.e. NYHA class II) or marked limitation in activity (i.e. NYHA class III)
* Able to perform cognitive and physical training.

Exclusion Criteria:

* Acute cardiovascular event 1 month prior to randomization, including emergency visit or hospitalization for decompensated HF, acute myocardial infarction, stroke, and transient ischemic attack
* Planned cardiovascular intervention within 6 months (implantation of any cardiac device, cardiac revascularization, heart transplantation)
* Severe exercise intolerance
* Contraindications for exercise testing (e.g., uncorrected severe aortic or carotid stenosis, severe pulmonary hypertension, severe non-revascularizable coronary disease including left main coronary stenosis, significant myocardial ischemia or arrhythmia during low-intensity exercise, acute HF)
* Severe respiratory disease
* Non-cardiopulmonary limitation to exercise (e.g., arthritis, claudication or any peripheral neurological disease including other neurodegenerative diseases such as disabling Parkinson)
* Uncontrolled diabetes or untreated thyroid dysfunction
* Current or recent malignancy with life expectancy \< 1 year
* Chronic hemodialysis or peritoneal dialysis
* Unable to read the informed consent form or unable to understand the oral explanations provided by the assessor.