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This study examines the mode of action of sodium butyrate in the human colon. It enrolled participants who met the Rome IV criteria for irritable bowel syndrome (IBS) as well as healthy individuals. It was a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * signed informed consent * Fulfilled Rome IV diagnostic criteria for IBS (for IBS participants) Exclusion Criteria: * known gastrointestinal diseases * previous complicated gastrointestinal surgery (including e.g. appendectomy or cholecystectomy) * pregnancy or breast-feeding * use of antibiotics within the last 12 weeks before the colonoscopy procedure * regular consumption of probiotics within the last 4 weeks before the colonoscopy procedure * use of laxatives or anti-diarrhoeals within the last 4 weeks before the colonoscopy procedure * use of serotonin selective re-uptake inhibitors (SSRI) or serotonin nor-epinephrine re-uptake inhibitors (SNRI) with the last 12 weeks before the colonoscopy procedure * alcohol or drug abuse * latex allergy * any other clinically significant disease/condition which in the investigator's opinion could interfere with the results of the study.