The Effect on Metabolism, Food Intake and Preferences of a Knockout Gene Variant Involved in Carbohydrate Metabolism

Plain-language summary

This study examines how the c.273_274delAG variant in the SI gene, which is involved in carbohydrate metabolism, affects metabolism, food intake and food preferences, using a cross-over design. It included people who carry two copies of this variant as well as a comparison group who do not carry it. The study had no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Steno Diabetes Center Copenhagen

Intervention

Cross-over study

Start date

1/8/2022

Estimated completion

5/7/2022

Countries

Greenland

Related genes

Locations

• Maniitsoq, Greenland
• Nuussuaq, Greenland

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Homozygous carriers of the c.273\_274delAG variant in the SI-gene (cases)
* Homozygous non-carriers of the c.273\_274delAG variant in the SI-gene (controls)

Exclusion Criteria:

* Diagnosis of diabetes or pharmacological treatment of diabetes.
* Gastrointestinal diseases such as inflammatory bowel disease, gastrointestinal cancer, and ulcer. Persons with mild gastrointestinal problems are not excluded, e.g. persons with lactose-intolerance who normally do not have any gastrointestinal problems.
* Homozygous carriers of the TBC1D4 risk variant p.Arg684Ter.
* Lack of compliance with the procedures in the study protocol, judged by Investigator.
* For the homozygous carriers of the c.273\_274delAG variant: rise in blood glucose in an oral sucrose tolerance test.