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This study examines the diversity and properties of anti-drug antibodies (IgE and IgG) involved in sudden allergic (hypersensitivity) reactions in the operating room. It includes patients aged 18-70 who had an allergic reaction during surgery in the past 10 years and underwent an allergy-anesthesia consultation. The study has no assigned phase and is still recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: Common to both groups: * Age ≥ 18 years old and ≤ 70 years old * Patient having presented an allergic reaction in the operating room in the last 10 years, regardless of the grade of severity, the causative agent or the type of anesthesia * Patient having benefited from an allergy-anaesthesia consultation in the investigator center For IgE group: \- presence of at least one positive skin test to one of the suspected agent (curare and/or antibiotic) during the allergist consultation For the IgG group: \- presence of circulating IgG-type antibodies directed against one of the suspected agents (curare, antibiotic, antiseptic), identified in the routine biological tests carried out at the time of the shock and / or the consultation of allergology. Exclusion Criteria: Common to both groups: * Absence of written informed consent * Protected person: under guardianship or curatorship * Patient without social security * Pregnancy of breast feeding * Ongoing immunosuppressive or chemotherapy * Acute heart failure * Patient included in another interventional research with an exclusion period For IgE group: * Taking oral or injectable anticoagulants * Taking a double antiplatelet aggregation * Previous sternotomy * Previous thoracic radiation therapy * Known allergy to local anesthesic or iodinated skin products * Previous major sternal cutaneous lesions Prerequisites for carrying out the sternal sample in order to carry out a myelogram (IgE group): * Leukocytes \> 4 giga/L in the 2 months preceding inclusion * Platelets \> 100,000 / mm3 in the 2 months preceding inclusion For the IgG group * Orthostatic hypotension * Realization of a blood donation in the 6 to 8 weeks preceding inclusion Prerequisites for performing the blood sample (IgG group): \- Hemoglobin \> 12.5 g/dL for women and \> 13 g/dL for men in the 2 months preceding inclusion