Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS

Plain-language summary

This study examines changes over time in the autonomic and sensory nervous system in patients with ALS (amyotrophic lateral sclerosis), using methods such as skin biopsy, cardiovascular reflex testing, and a sweat test. It enrolls ALS patients within 18 months of the onset of their motor symptoms. It is a trial without an assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Istituti Clinici Scientifici Maugeri SpA

Intervention

Skin biopsy, Cardiovascular Reflexes testing, Administration of clinical scales evaluating autonomic symptoms, pain small fiber neuropathy symptoms, Dinamic Sweat Test

Start date

5/15/2021

Estimated completion

12/30/2026

Countries

Italy

Related genes

Locations

• Telese Terme, Italy
• Naples, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* ALS patients will be recruited within 18 months from the motor symptoms onset

Exclusion Criteria:

* glucose intolerance or conditions potentially affecting the peripheral nervous system