Dietary Supplementation With Blueberry in OA

Plain-language summary

This study examines the effects of a blueberry powder supplement compared with a placebo-like supplement (maltodextrin) in patients awaiting total knee replacement due to osteoarthritis. It enrolled patients over 40 with knee osteoarthritis who are scheduled for total knee replacement. It is a study without an assigned phase; it is not currently recruiting but is ongoing (active, not recruiting).

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Active, not recruiting

Sponsor

University of Exeter

Intervention

Blueberry powder supplement, Maltodextrin supplementation

Start date

5/22/2023

Estimated completion

9/1/2027

Countries

United Kingdom

Related genes

Locations

• Honiton, United Kingdom

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Participants capable of giving informed consent
* Sex: Male and female
* Age: \> 40 years - Those under 40 are more likely to have an undiagnosed secondary cause of osteoarthritis
* BMI: \> 18 kg/m2
* Listed to have a total knee replacement for osteoarthritis
* Participants are permitted to participate in other ongoing surgical intervention studies, as long as these are not trials of a dietary supplement or a medication.

Exclusion Criteria:

* Those who have received intravenous or oral immunosuppressant medications in past 2 years
* Those who have had intra-articular steroid injection in 6 months preceding surgery.
* Some secondary causes of osteoarthritis (mechanistic confounders that are likely to influence tissue inflammation measures:
* Known congenital joint disorders
* Other inflammatory arthritis e.g. rheumatoid arthritis
* Avascular necrosis, infectious arthritis
* Paget disease
* Osteopetrosis
* Osteochondritis dissecans
* Hemochromatosis
* Wilson's disease
* Hemoglobinopathy
* Ehlers-Danlos syndrome
* Marfan syndrome
* Acromegaly
* Those typically consuming more than eight 80 g portions (or juice equivalent) of blueberries, blackberries, strawberries, raspberries, blackcurrants, pomegranate or cherries per week
* Those with a known fruit allergy, for which they carry an adrenaline auto-injector or have required anti-histamine, adrenaline, glucocorticoid or beta-agonist treatment.
* Those who cannot adequately understand verbal explanations or written information given in English