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This study examines exercise capacity (VO2max) and health-related quality of life (HRQoL) in children with sickle cell disease. It included children aged 6 to 17 with a confirmed diagnosis, along with healthy children for comparison. It was a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Sickle cell children Inclusion Criteria: * Child from 6 to 17 years old, with a confirmed diagnosis of sickle cell disease (i.e., homozygous HbS/S or heterozygous HbS/C mutations), during their routine follow-up, having performed : * a hematology consultation : physical examination, blood test * a cardiology consultation : electrocardiogram, transthoracic echocardiography * a respiratory plethysmography * a CPET and to fill in the study questionnaires. Exclusion Criteria: * Parents' refusal to use medical data. Healthy children Inclusion Criteria: * Child from 6 to 17 years old having performed a cardio-respiratory exercise test for chest pain, dyspnea on exertion, heart murmur and whose results do not find: * Congenital heart disease (normal echocardiography and ECG) * Respiratory disease (normal FEV1 and FVC) * Child having performed a maximal cardio-respiratory stress exercise until exhaustion. Exclusion Criteria: * Child taking long-term drug treatment * Child with chronic disease * Parents' refusal to use medical data.