Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome

Plain-language summary

This study examines the relationship between gum health (periodontal status) and dysfunction of the inner lining of blood vessels (endothelial dysfunction) in women with polycystic ovary syndrome (PCOS). Women diagnosed with PCOS by the Rotterdam criteria were compared with healthy women of similar age and body mass index. The study was conducted as a non-phase observational study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Start date

2/1/2020

Estimated completion

9/1/2022

Countries

Spain

Related genes

Locations

• Valencia, Spain

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Women with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria:

  1. Irregular ovulation (cycles longer than 35 days or less than 26 days)
  2. Elevated levels of free testosterone (\>0.5 ng/dl)
  3. Hirsutism and the presence of polycystic ovaries
* Healthy women without periodontal diseases matched in BMI and age to the PCOS group.

Exclusion Criteria:

* Other systemic inflammatory conditions
* Recent antibiotic use
* Chronic anti-inflammatory use
* Cancerous or bone-affecting pathologies
* Diabetes or autoimmune diseases
* Use of any medication during the previous semester