Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome

Plain-language summary

This study evaluates implementing a diagnostic workflow (anti-nephrin antibodies and u-RPC cultures) for the personalized diagnosis of nephrotic syndrome. It enrolls patients diagnosed with nephrotic syndrome whose disease began before age 40. It is a study with no assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Meyer Children's Hospital IRCCS

Intervention

Anti-nephrin antibodies, u-RPC cultures

Start date

1/26/2022

Estimated completion

6/30/2026

Countries

Italy

Related genes

Locations

• Florence, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Clinical diagnosis of NS (SSNS, SRNS, or NS relapsed after transplantation regardless of initial response to steroid therapy)
* Age below 40 years at disease onset
* Availability of clinical information
* Signed informed consent form

Exclusion Criteria:

* Age at onset above 40 years
* Kidney biopsy proving lesions other than FSGS and MCD