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This study examines the relationship between endometriosis-related pain and lifestyle, investigating the effect of an anti-inflammatory diet and cognitive behavioral therapy. It enrolls women aged 17 and older with endometriosis confirmed by ultrasound, MRI, or surgery whose pain level is above a certain threshold. It is a study without a designated phase and is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Confirmed diagnosis of endometriosis via ultrasound, MRI or surgery\* * NRS pain score \> 4\* * Age from 17 years * Premenopausal status * Body Mass Index (BMI) 18-30 kg/m2 * Ability to understand the explanation about the diet intervention (DI) and CBT\* * Willing to follow the DI\* * Willing to continue their use of food supplements * Willing to undergo CBT\* * Willing to collect menstrual effluent, and therefore willing to have two stop weeks from hormonal contraception (if applicable) during the study period. Exclusion Criteria: * Recurrent miscarriages (\> 2) * Eating disorder * Diagnosed with Crohn's disease, Ulcerative Colitis, short bowel syndrome or another chronic inflammatory disease * Self-reported celiac disease * Vegan diet * Smoking * Use of immunosuppressive or psychotropic medication * Score on FFQ \> 120 * Diagnosed with severe mental disorder currently requiring treatment by psychiatrist * NRS average score below 4 during the last month * Participation in another intervention study * Unable to speak Dutch or to understand the intervention * Need for surgery during the participation in the study * Serious pain (NRS \> 4) from other origin than endometriosis * Pregnant * Scalp hair shorter than 4 cm * Only applicable to patients with endometriosis