Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease

Plain-language summary

This study examines non-motor symptoms in people with Parkinson's disease related to the glucocerebrosidase (GBA) gene. It is enrolling patients who meet Parkinson's disease criteria and carry a heterozygous mutation in the glucocerebrosidase gene, as well as controls without the mutation. It is being run as a study with no assigned phase and is enrolling by invitation.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Enrolling by invitation

Sponsor

Juan Pablo Romero. MD, PhD

Intervention

Tests on non motor symptoms

Start date

7/1/2024

Estimated completion

8/31/2026

Countries

Spain

Related genes

Locations

• Pozuelo de Alarcón, Spain
• Madrid, Spain

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Aged over 18 years old.
* Fulfill Parkinson's disease criteria of Movement Disorder Society 2015.
* Parkinson's disease symptoms began before they were 70 and/or Parkinson's disease family history.
* Underwent a genetic test of Parkinson's disease related genes.
* Heterozygous mutation of glucocerebrosidase gene (only cases).
* Absence of mutation in the Parkinson's disease genetic test (only controls).

Exclusion Criteria:

* Suspicion of atypical parkinsonism.
* Personal history of other neurodegenerative disorders such as Alzheimer's disease.
* Personal history of significant cerebrovascular damage, intracraneal lessions or important craneoencephalic trauma.
* Deep brain stimulation treatment for Parkinson's disease.
* Moderate or severe dementia that precludes from performing the tests.