Evaluating the Role of IGF-1 and S-Klotho In Plaque Phenotype and Vulnerability: the VISION Study.

Plain-language summary

This study evaluates the role of the markers IGF-1 and S-Klotho in the structure and vulnerability of arterial plaques. It enrolls patients aged 18 and older undergoing coronary angiography and OCT imaging for chronic coronary syndrome. It is a study with no assigned phase and is currently not recruiting but ongoing (active, not recruiting).

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Active, not recruiting

Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Intervention

Coronary angiography with OCT

Start date

10/15/2024

Estimated completion

12/31/2026

Countries

Italy

Related genes

Locations

• Roma, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Patients with chronic coronary syndrome undergoing coronary angiographic study.
* Patients undergoing intravascular imaging with OCT during coronary angiographic study at the operator's discretion, for diagnostic purposes and/or to guide possible coronary artery disease treatment.
* Patients with at least 18 years of age.
* Patients able to provide informed consent.

Exclusion Criteria:

* Pregnancy.
* Pathological excess or deficiency of IGF-1.
* Stage IV chronic renal failure.
* Severe liver disease.
* Cachexia and/or malnutrition states.
* BMI \<18.5.
* HbA1C ≥ 8.5%.
* Left Ventricle Ejection Fraction (LVEF) \<= 35%
* Patients with aorto-coronary bypass.
* OCT analysis conducted on vessels with previous percutaneous coronary intervention with stent implantation.