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This study explores the short-term effects of glucocorticoid (a stress hormone) secretion during high calorie intake in overweight and obese individuals. It compared the drugs Metyrapone and Hydrocortisone with placebo; participants were men aged 18-50 with a body mass index of 25 or above. It was carried out as a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Males aged 18 to 50 years * BMI≥ 25 kg/m² with a stable weight within past three months before study initiation Exclusion Criteria: * Any severe acute or chronic disease, including diabetes mellitus type 2 * Intake of GLP-1 agonists or hormone therapy * Hypercortisolism * Casual smoking (more than 6 cigarettes per day) * Frequent, heavy alcohol consumption (more than 30g/day) * Frequent, heavy caffeine consumption (more than 4 caffeinated drinks/day) * Regular physical exercise (more than 4hrs per week) * Shift work * Participation in an investigational drug trial within the past two months * Intake of any steroid-containing drugs, including topical steroids and inhalers, within 4 weeks of the study initiation * Known allergy to metyrapone * Inability or unwillingness to provide informed consent