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This study assesses how reproducible and consistent a fatigability test (a thumb test, grip test, and quadriceps intermittent fatigue test) is when adapted for people with spinal muscular atrophy (SMA). It enrolls patients aged 6 and older with a genetically confirmed SMA diagnosis who have not had orthopedic surgery in the past 6 months. Run by Centre Hospitalier Universitaire de Saint Etienne, this study does not use clinical phases and is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Genetically confirmed spinal muscular atrophy * Age ≥ 6 years * No orthopaedic surgery in the 6 months prior to inclusion * Informed consent signed by the patient(s) or parent(s)/legal guardian(s) and assent of the patient * Affiliated or beneficiary of a health insurance scheme (for inclusion in France) Exclusion Criteria: * Other condition that may significantly interfere with the assessment of the SMA and which is clearly unrelated to the disease * Other associated neurological disease * Joint deformities that prevent correct and comfortable positioning with the various different measuring devices (thumb-index clamp, handgrip and QIF-test) * Contraindication to transcranial magnetic stimulation