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This research studies the risk of developing chronic hepatitis linked to chronic enteric virus infection in patients with primary immunodeficiency or secondary humoral deficiency, by collecting plasma, urine, and stool samples. Patients of any age with defined types of immunodeficiency may take part. It is a non-phase research study that is currently recruiting.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: \- Information and non-opposition from the legal representatives of minor patients, the patients themselves and adult patients of the population of interest. Population of interest: Patients with no age limit followed in one of the skills centers of the Reference Center for Hereditary Immunodeficiencies (CEREDIH) within the APHP (Necker-Enfants Malades hospital, Saint-Louis Hospital and Cochin hospital) and presenting: * Humoral primary immunodeficiencies (PIDs) defined according to the IUIS (International Union of Immunological Societies) criteria * Secondary form of humoral immunodeficiencies (post anti-CD20 monoclonal antibody or post CAR-T cells therapy with alymphocytosis B and/or hypo IgA or IgM or IgG) * Combined immunodeficiency (CID) defined according to the IUES criteria * Severe combined immunodeficiency (SCID) beyond 2 years post cell therapy (allogeneic haematopoietic stem cell transplantation (aHSCT) or gene therapy) Exclusion Criteria: * Patients not belonging to one of the target populations * Opposition of legal representatives of minor patients, patients themselves and adult patients