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This study looks at the role of different sugars (glucose, fructose, and sucrose) in fat accumulation in the liver, along with the effect of short-term fructose restriction. Male volunteers aged 18 to 70 can take part, and one part of the study includes people with fatty liver (hepatic steatosis). It is a study with no applicable phase and is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Part A Inclusion Criteria: * male volunteers - 15 nonobese subjects (Body Mass Index (BMI) \< 30 kg/m2) and 15 obese subjects (BMI ˃ 30 kg/m2) * 18 - 70 years old Exclusion Criteria: * diabetes mellitus (fasting glucose above 7 mmol/l, 2-hour glucose after oGTT above 11.1 mmol/l, or antidiabetic treatment) * other serious illnesses (cardiovascular disease, cancer, etc.) * alcohol consumption ˃ 30 g/day * fructose intolerance * use of drugs affecting lipid metabolism Part B Inclusion Criteria: * male volunteers with hepatic fat content higher than 6.2% and less than 16.5%, which corresponds to steatosis grade 2 (S2) * 18 - 70 years old Exclusion Criteria: * diabetes mellitus (fasting glucose above 7 mmol/l, 2-hour glucose after oGTT above 11.1 mmol/l, or antidiabetic treatment) * other serious illnesses (cardiovascular disease, cancer, etc.) * alcohol consumption ˃ 30 g/day * use of drugs affecting lipid metabolism * intolerance of MR examination (claustrophobia, metal implants, etc.).