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This study investigates the links between gene expression and metabolomics in fat (adipose) tissue and the gut microbiome-brain axis. Men and women over 20 years old who are scheduled for surgery that involves removing adipose tissue may take part. Conducted by Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, this study without an assigned phase is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Men and women \>20 years old. * Scheduled for surgical intervention to extract adipose tissue. * Signed informed consent for study participation. Exclusion Criteria: * Not meeting inclusion criteria. * Non-obesity-related systemic diseases (cancer, severe kidney/liver disease). * Systemic diseases with intrinsic inflammation (rheumatoid arthritis, Crohn's disease, asthma, chronic infections (HIV/tuberculosis)) or any type of infectious disease. * Pregnant/breastfeeding women. * Persons under legal/administrative restrictions. * Those with infection symptoms in the past month. * Use of antibiotics/antifungals/antivirals (previous 3 months). * Chronic steroidal/anti-inflammatory drug use. * Major psychiatric history. * Excessive alcohol intake, acute or chronic (\>40g/day (women), \>80g/day (men)) or drug abuse. * Immunosuppressants treatment. * Participants with severe eating disorders. * Serum liver enzymes (GOT, GPT) above twice the upper limit of normal. Obvious signs or symptoms of liver disease, acute or chronic hepatitis. * History of iron balance disorders (e.g., genetic hemochromatosis, hemosiderosis from any cause, atransferrinemia, paroxysmal nocturnal hemoglobinuria). * Creatinine greater than 1.2 and glomerular filtration rate below 40. * Current treatment for malignant neoplasia, other than basal cell or squamous cell skin cancer. * Heart disease classified as class III or IV, known ischemic cardiovascular disease. * Renal failure, history of kidney transplant, or current dialysis treatment. * Chronic constipation (bowel movement frequency ≥ 7 days) .