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This study examines how metabolic responses to rapidly digestible, slowly digestible and resistant starch differ from person to person. Men and postmenopausal women aged 30-75 who meet certain body mass index and waist circumference criteria may take part. Conducted by Chalmers University of Technology, this study without an assigned phase is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Men and post-menopausal women * Age 30-75 years * BMI 27-40 kg/m2 * Waist circumference \> 102/88 cm for men/women * Weight stable during previous 3 months (± 3 kg) * Willingness to consume the intervention diets * Ability to deal with the monitoring devices * Medications stable for the previous 14 days * Signed informed consent Exclusion Criteria: * Cardiovascular events (myocardial infarction or stroke) during the previous 6 months * Diagnosis of diabetes (any type) or use of any drug who can interfere with glucose homeostasis (i.e., metformin, incretin analogues, SGLT-2 inhibitors) * History of stomach or gastrointestinal conditions (inflammatory bowel disease, Crohn's disease, malabsorption, etc.) * Colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery * Renal or liver failure (creatinine \<1.7 mg/dl and alanine aminotransferase/aspartate aminotransferase \< 2 times than normal values, respectively) * Anemia (hemoglobin below the age and sex specific normal reference ranges at screening) * Blood donation (or participation in a clinical study with blood sampling) within 30 days prior to inclusion * Having been treated with antibiotics within the past 3 months or planning to undergo treatment during the study period. * Habitual use of probiotic/prebiotic supplements or foods enriched in probiotics * Celiac disease * Vegan/vegetarian diet (or a diet incompatible with protocol diets) * Intense physical activity regimen (\> 7 h/week of moderate intensity or \> 3 h/week of high intensity) * History of drug or alcohol abuse * Not able to understand written and spoken Swedish * Any other reason for lack of suitability for participation in the trial, as judged by the principal investor or co-principal investigator